There are several ways to administer ozone gas, but it shouldn’t be inhaled. This can cause severe irritation and fluid buildup in your lungs. Safer methods for delivering ozone therapy include:

Applying it to your skin by exposing a section of your body to ozone gas under a protective covering (also called ozone sauna) or by applying an ozone solution to your skin (often for wound healing).

• Blowing gas into your body, typically through your ears, rectum or vagina.
• Mixing it with your blood. Ozone gas can be dissolved in a sample of your blood and then reintroduced back into your body through an IV through a process called autohemotherapy.
• Ingesting it by consuming small amounts of ozone gas dissolved in oil or water.
• Injecting it into one of your muscles through a shot containing a mixture of oxygen and ozone.

There is low-quality and limited evidence that ozone therapy could offer health benefits. These include:

• Immune system support because ozone therapy activates your immune system and boosts immunity.
• Improved blood circulation, as more oxygen travels to your cells, tissues and organs.
• Protection from invaders like bacteria, viruses and fungi by halting their growth and reducing their survival.
• Reduced oxidative stress, which is an imbalance of cell-damaging free radicals and protective antioxidants that can lead to inflammation and chronic disease.

“Ozone therapy functions like an antioxidant or anti-inflammatory,” says Dr. Tejwani. “It could potentially be used for any type of inflammation, whether in a wound or related to conditions such as diabetes or arthritis.”

Research is ongoing to determine the safety and potential uses of ozone therapy. But it has been studied for conditions such as:

• Breathing disorders, like chronic obstructive pulmonary disease (COPD).
• Cancer.
• Diabetes.
• Fibromyalgia.
• Immune disorders such as human immunodeficiency virus (HIV).
• Musculoskeletal disorders like disk herniation or carpal tunnel syndrome.

The FDA has yet to authorize or regulate ozone therapy. For now, the possible side effects outweigh the potential health benefits, says Dr. Tejwani.

Some potential side effects of ozone therapy include:

• Air embolism: If air bubbles form during IV ozone therapy, they can cause a blocked vein or artery and a potentially serious condition such as a stroke or heart attack.
• Discomfort and cramping: These side effects can occur when ozone gas is blown into your body, usually through your rectum.
• Herxheimer reaction: You may experience some flu-like symptoms as ozone therapy relieves inflammation and kills viruses and bacteria.

Breathing in medical-grade ozone, even in very low doses, is harmful. Short-term exposure to a small amount of ozone can cause severe and permanent damage to your lungs and respiratory system.

Inhaling ozone is never recommended, but it can happen accidentally — especially if you attempt to administer it yourself. As ozone is unpredictable and unstable, it requires precision in the amount used and how it’s administered. Never attempt to do it yourself.

The initial effects of breathing in ozone may be burning eyes, coughing, nausea or a headache. But the long-term effects could be severe.

“If you inhale the ozone in the environment, you won’t get lung disease after a single inhalation,” states Dr. Tejwani. “But if you inhale some unregulated and unstandardized amount of ozone, it could potentially cause an acute lung injury.”

Over time, inhaled ozone could lead to chronic lung diseases such as asthma or COPD, or worsen any preexisting lung disease.

There just isn’t enough evidence to confirm that ozone therapy is safe, cautions Dr. Tejwani.

Ozone therapy hasn’t been tested in large-scale clinical trials conducted on humans. Until that happens and there’s a better understanding of the risks versus rewards, ozone therapy will continue to be an unregulated, alternative therapy.

“There are just so many steps to go,” Dr. Tejwani adds. “There’s a lot of work to be done as far as standardizing the dosage, clarifying what illnesses ozone therapy would be effective for and ensuring it’s administered the right way.”